Endocrinology and Metabolism

Deog Yoon Kim (Kim DY)

11 Articles

Medical Service Utilization with Osteoporosis.: Sunmee Jang, Chanmi Park, Suhyun Jang, Hyun Koo Yoon, Chan Soo Shin, Deog Yoon Kim, Yong Chan Ha, Seong Su Lee, Hyung Jin Choi, Young Kyun Lee, Bom Taeck Kim, Ji Yeob Choi; Endocrinol Metab. 2010;25(4):326-339. Published online December 1, 2010; DOI: https://doi.org/10.3803/EnM.2010.25.4.326

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BACKGROUND
Although osteoporosis is increasing in the elderly population, attempts to analyze the patterns of medical service utilization for osteoporosis are currently not sufficient. The medical services and treatment patterns were investigated using Korea's National Health Insurance claims data, which includes all of the Korean population. METHODS: Through the patient identification algorithm developed by using the administrative claims data in 2007, the adult patients (between 50-100 years) with osteoporosis were identified. The age and gender of the patients who used medical service for osteoporosis were described, in relation with six dichotomous variables. The medical service use patterns such as the type of medical institution and conducting bone mineral density measurement were investigated. RESULTS: The number of patients who used medical service were 1,230,580 (females 89.9%). Sixty one point six percent of the patients were prescribed osteoporosis medicine (indicated for osteoporosis only), and 12.9% of the patients had experienced osteoporotic fracture. The primary medical institutions for treatment were clinics (54.3%), while hospitals were mainly used among the patients with a history of fracture and disease or drug use that may induce secondary osteoporosis. The number of visited medical institutions was 6.4 (as an outpatient) and 0.2 (as admissions) during 6 months. The proportion of patients who conducted bone mineral density measurements within one year before and after the diagnosis of osteoporosis was 66.7% and DXA was the most frequently used densitometry (46.3%). The average number of days for the prescriptions for osteoporosis medicine was 70 days. CONCLUSION: In order to prevent further osteoporotic fractures, appropriate management and treatment should be implemented for osteoporosis patients. To do this, we need to understand the current state of medical service utilization and the treatment of osteoporosis using the National Health Insurance claims data.

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Nationwide sample data analysis of additional surgery rate after anterior or posterior cervical spinal surgery
Woon Tak Yuh, Minjung Kim, Yunhee Choi, Junghoon Han, Junhoe Kim, Taeshin Kim, Chun Kee Chung, Chang-Hyun Lee, Sung Bae Park, Kyoung-Tae Kim, John M. Rhee, Moon Soo Park, Chi Heon Kim
Scientific Reports.2023;[Epub] CrossRef
Evaluating the effect of the COVID-19 pandemic on hypertension and diabetes care in South Korea: an interrupted time series analysis
Boram Sim, Sunmi Kim, Eun Woo Nam
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Anti-Müllerian Hormone promotes human osteoblast differentiation and calcification by modulating osteogenic gene expression
Francesca Liuzzi, Marilena Taggi, Serena De Carlini, Antonio La Marca
Gynecological Endocrinology.2023;[Epub] CrossRef
Risk factors for reoperation after lumbar spine surgery in a 10-year Korean national health insurance service health examinee cohort
Sung Hyun Noh, Pyung Goo Cho, Keung Nyun Kim, Boeun Lee, Jae Kwang Lee, Sang Hyun Kim
Scientific Reports.2022;[Epub] CrossRef
Comparative analysis of cardio-cerebrovascular complications in immigrants and native-born Koreans with diabetes: Risk factors and perspectives
Hyemin Cho, Sohyun Jeoung, Cinoo Kang, Sunmee Jang, Chaisiri Angkurawaranon
PLOS ONE.2022; 17(4): e0263046. CrossRef
Cost-Effectiveness of Denosumab for the Treatment of Postmenopausal Osteoporosis in South Korea
Jung-Yoon Kang, Leejung Choi, Ben Johnson, Hyowon Yang
Journal of Bone Metabolism.2022; 29(2): 83. CrossRef
Measures of physical performance as a predictor of fracture risk independent of BMD: The Chungju metabolic disease cohort study
Yejee Lim, Jeonghoon Ha, Kun Ho Yoon, Ki Hyun Baek, Moo-Il Kang
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Characteristics of Osteoporosis & Osteoporotic Fractures in Korea Based on Health Insurance Review and Assessment (HIRA) Database: 2009–2017
Ho-Seok Oh, Sung-Kyu Kim, Hyoung-Yeon Seo
Healthcare.2021; 9(3): 324. CrossRef
Treatment Patterns of Osteoporosis and Factors Affecting the Prescribing of Bone-forming Agents: From a National Health Insurance Claims Database
Jihae Jeong, Ju-Young Shin
Korean Journal of Clinical Pharmacy.2021; 31(1): 27. CrossRef
Estimating the future clinical and economic benefits of improving osteoporosis diagnosis and treatment among women in South Korea: a simulation projection model from 2020 to 2040
Micah Jackson, Kyu Hyun Yang, Matthew Gitlin, Zachary Wessler
Archives of Osteoporosis.2021;[Epub] CrossRef
Long-Term Effect of Diabetes on Reoperation After Lumbar Spinal Surgery: A Nationwide Population-Based Sample Cohort Study
Chang-Hyun Lee, Chi Heon Kim, Chun Kee Chung, Yunhee Choi, Min-Jung Kim, Dahae Yim, Seung Heon Yang, Dong Hwan Kim, Young San Ko, Sung Bae Park
World Neurosurgery.2020; 139: e439. CrossRef
Incidence and Management Trends of Osteoporotic Vertebral Compression Fractures in South Korea: A Nationwide Population-Based Study
Sung Hoon Choi, Dong-Yun Kim, Ja Wook Koo, Seung Gun Lee, Soo-Young Jeong, Chang-Nam Kang
Asian Spine Journal.2020; 14(2): 220. CrossRef
Identification of herpes zoster high‐risk group using Charlson comorbidity index: A nationwide retrospective cohort study
Soo Ick Cho, Dong Hun Lee, Young Min Park
The Journal of Dermatology.2020; 47(1): 47. CrossRef
The Impact of Korean Medicine Treatment on the Incidence of Parkinson’s Disease in Patients with Inflammatory Bowel Disease: A Nationwide Population-Based Cohort Study in South Korea
Hyeonseok Noh, Jeongju Jang, Seungwon Kwon, Seung-Yeon Cho, Woo-Sang Jung, Sang-Kwan Moon, Jung-Mi Park, Chang-Nam Ko, Ho Kim, Seong-Uk Park
Journal of Clinical Medicine.2020; 9(8): 2422. CrossRef
The Long-term Reoperation Rate Following Surgery for Lumbar Stenosis
Jong-myung Jung, Chun Kee Chung, Chi Heon Kim, Yunhee Choi, Min-Jung Kim, Dahae Yim, Seung Heon Yang, Chang Hyun Lee, Sung Hwan Hwang, Dong Hwan Kim, Joon Ho Yoon, Sung Bae Park
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Assessing the effects of National Health Insurance reimbursement policy revisions for anti-osteoporotic drugs in Korean women aged 50 or older
Ja Seo Koo, Seong Hwan Moon, Hankil Lee, Sohee Park, Yun Mi Yu, Hye-Young Kang, Robert Daniel Blank
PLOS ONE.2020; 15(12): e0244759. CrossRef
Association between Relative Handgrip Strength and Osteoporosis in Older Women: The Korea National Health and Nutrition Examination Survey 2014–2018
Kwang-Ho Ahn, Yunhwan Lee, Tae-yong Sohn, Dong Yun Kim, Mikyung Ryu, Ho Gym, Sol Lee
Annals of Geriatric Medicine and Research.2020; 24(4): 243. CrossRef
Depression Risk among Patients with Open-angle Glaucoma: a 10-year Follow-up Nationwide Cohort Study
Sang Yeop Lee, Tyler Hyungtaek Rim, Hyoung Won Bae, Gong Je Seong, Sung Soo Kim, Chan Yun Kim
Journal of the Korean Glaucoma Society.2019; 8(2): 44. CrossRef
The impact of differential cost sharing of prescription drugs on the use of primary care clinics among patients with hypertension or diabetes
Eunja Park, Daeeun Kim, Sookja Choi
Public Health.2019; 173: 105. CrossRef
Risk of osteoporosis in patients with chronic inflammatory neuropathy- a population-based cohort study
Seung Woo Kim, Eun Hwa Kim, Jinae Lee, Young-Chul Choi, Seung Min Kim, Ha Young Shin
Scientific Reports.2019;[Epub] CrossRef
The Long-term Reoperation Rate Following Surgery for Lumbar Herniated Intervertebral Disc Disease
Chi Heon Kim, Chun Kee Chung, Yunhee Choi, Min-Jung Kim, Dahae Yim, Seung Heon Yang, Chang Hyun Lee, Jong-Myung Jung, Sung Hwan Hwang, Dong Hwan Kim, Joon Ho Yoon, Sung Bae Park
Spine.2019; 44(19): 1382. CrossRef
Comparison of screening strategies for prevalent vertebral fractures in South Korea: vertebral fracture assessment vs. spine radiography
Sung-Hee Oh, Dam Kim, Young Eun Lee, Deog-Yoon Kim, Yu Kyung Lee, Joo-Hyun Lee, Sang-Cheol Bae, Yun Young Choi, Junhee Pyo, Jeonghoon Ahn, Yoon-Kyoung Sung
BMC Musculoskeletal Disorders.2018;[Epub] CrossRef
Utilization of Osteoporosis-Related Health Services: Use of Data from the Korean National Health Insurance Database 2008–2012
Tae Yang Yu, Hyemin Cho, Tae-Young Kim, Yong-Chan Ha, Sunmee Jang, Ha Young Kim
Journal of Korean Medical Science.2018;[Epub] CrossRef
Effect of improved medication adherence on health care costs in osteoporosis patients
Hyemin Cho, Ji-Hye Byun, Inmyung Song, Ha Y. Kim, Yong-Chan Ha, Tae-Young Kim, Young-Kyun Lee, Sunmee Jang
Medicine.2018; 97(30): e11470. CrossRef
Risk Factors for Bone Loss in Patients Having Clinical Conditions That Restrict Physical Activity
Myung Kyung Lee
Rehabilitation Nursing.2018; 43(1): 12. CrossRef
Increased risk of open‐angle glaucoma among patients with diabetes mellitus: a 10‐year follow‐up nationwide cohort study
Tyler Hyungtaek Rim, Sang Yeop Lee, Hyoung Won Bae, Gong Je Seong, Sung Soo Kim, Chan Yun Kim
Acta Ophthalmologica.2018;[Epub] CrossRef
Characteristics of Patients Diagnosed with Osteoporosis in South Korea: Results from the National Claim Registry
Hyun Koo Yoon, Young-Kyun Lee, Yong-Chan Ha
Journal of Bone Metabolism.2017; 24(1): 59. CrossRef
Comorbidity Adjustment in Health Insurance Claim Database
Kyoung Hoon Kim
Health Policy and Management.2016; 26(1): 71. CrossRef
Gender- and age-group-specific associations between physical performance and bone mineral density, falls, and osteoporotic fractures in Koreans: the Chungju Metabolic Disease Cohort study
Yejee Lim, Kyunghee Kim, Sun-Hee Ko, Kwanhoon Cho, Eun-Hee Jang, Seung-Hwan Lee, Dong Jun Lim, Ki Hyun Baek, Hee-Sung Ha, Mi Sun Park, Hyeon-Woo Yim, Won-Chul Lee, Kun-Ho Yoon, Ho Young Son, Ki Won Oh, Moo-Il Kang
Journal of Bone and Mineral Metabolism.2016; 34(3): 336. CrossRef
Oral Bisphosphonates and Upper Gastrointestinal Cancer Risks in Asians with Osteoporosis: A Nested Case-Control Study Using National Retrospective Cohort Sample Data from Korea
Sun-Young Jung, Hyun Soon Sohn, Eun-Ja Park, Hae Sun Suh, Ji-Won Park, Jin-Won Kwon, Chi-Ling Chen
PLOS ONE.2016; 11(3): e0150531. CrossRef
A retrospective study on the management of osteoporosis in Parkinson's disease – A single institution, preliminary study
Kwang-Kyoun Kim, Tae-Kyun Kim, Yougun Won, Won-Sub Sung
Osteoporosis and Sarcopenia.2015; 1(1): 59. CrossRef
A Large National Cohort Study of the Association between Bisphosphonates and Osteonecrosis of the Jaw in Patients with Osteoporosis
J.-W. Kwon, E.-J. Park, S.-Y. Jung, H.S. Sohn, H. Ryu, H.S. Suh
Journal of Dental Research.2015; 94(9_suppl): 212S. CrossRef
Background and Data Configuration Process of a Nationwide Population-Based Study Using the Korean National Health Insurance System
Sun Ok Song, Chang Hee Jung, Young Duk Song, Cheol-Young Park, Hyuk-Sang Kwon, Bong Soo Cha, Joong-Yeol Park, Ki-Up Lee, Kyung Soo Ko, Byung-Wan Lee
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Factors Associated with the Treatment of Osteoporosis in Korean Postmenopausal Women
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Epidemiology of Osteoporosis and Osteoporotic Fractures in South Korea
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Journal of the Korean Association of Oral and Maxillofacial Surgeons.2013; 39(1): 9. CrossRef
Age-Related Changes in the Prevalence of Osteoporosis according to Gender and Skeletal Site: The Korea National Health and Nutrition Examination Survey 2008-2010
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Endocrinology and Metabolism.2013; 28(3): 180. CrossRef
National Utilization of Calcium Supplements in Patients with Osteoporotic Hip Fracture in Korea
Sang-Hwan Kim, Young-Bong Ko, Young-Kyun Lee, Seok-Woo Hong, Hyung-Jin Choi, Yong-Chan Ha, Chan-Soo Shin
Journal of Bone Metabolism.2013; 20(2): 99. CrossRef
Routine Application of the Korean FRAX Model in Women: a Single-center Study
Tae-Hee Kim, Hae-Hyeog Lee, Soo-Ho Chung, WooSeok Lee, Junsik Park, Sujin Lee
Korean Journal of Bone Metabolism.2012; 19(1): 29. CrossRef
The prevalence of osteoporosis in Korean adults aged 50 years or older and the higher diagnosis rates in women who were beneficiaries of a national screening program: The Korea National Health and Nutrition Examination Survey 2008–2009
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Journal of Bone and Mineral Research.2012; 27(9): 1879. CrossRef
Dietary factors affecting bone mineral density in Korean rural postmenopausal women
Jeong Sook Choe, Eun Mi Ahn, Sung Ok Kwon, Young Hee Park, Jinyoung Lee
Korean Journal of Nutrition.2012; 45(5): 470. CrossRef
Epidemiology and Economic Burden of Osteoporosis in South Korea
Yong-Chan Ha
Journal of the Korean Fracture Society.2011; 24(1): 114. CrossRef
Factors associated with the hypertension outpatients' choice of healthcare providers in Korea
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A Case of Osteomalacia Caused by Severe Vitamin D Deficiency.: Seok Yeon Kim, Sang Youl Rhee, Soo Young Moon, Suk Chon, In Kyung Jeong, Seungjoon Oh, Kyu Jeung Ahn, Deog Yoon Kim, Ho Yeon Chung, Sung Woon Kim, Jin Woo Kim, Young Seol Kim, Jeong Taek Woo; J Korean Endocr Soc. 2007;22(1):55-61. Published online February 1, 2007; DOI: https://doi.org/10.3803/jkes.2007.22.1.55

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Abstract PDF

Vitamin D is a kind of hormone that can be synthesized in the skin or it is supplied in the diet it is involved in a central role in bone and calcium homeostasis in vivo. Metabolic bone diseases such as rickets in children and osteomalacia in adults can also be caused by deficiency or metabolic defects in the vitamin D hormone related system. However, there has been a lack of generalized epidemiologic studies about the vitamin D deficiency status in Koreans. We recently experienced a case of osteomalacia caused by severe vitamin D deficiency. These kinds of case have not been reported elsewhere in Korea for the last twenty years.

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A Case of Nutritional Osteomalacia in Young Adult Male
Choong-Kyun Noh, Min-Jeong Lee, Bu Kyung Kim, Yoon-Sok Chung
Journal of Bone Metabolism.2013; 20(1): 51. CrossRef

A Case of Cystic Parathyroid Adenoma Presenting as Severe Bony Lesion.: Suk Chon, Young Hee Kim, Ji Young Park, Kwan Pyo Ko, Cheol Young Park, Deog Yoon Kim, Jeong Taek Woo, Sung Woon Kim, Jin Woo Kim, Young Seol Kim, Suck Hwan Go; J Korean Endocr Soc. 2003;18(2):214-220. Published online April 1, 2003

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Abstract PDF: A cystic parathyroid adenoma is rare. A case of primary hyperparathyroidism, with the cystic formation of a parathyroid adenoma and a severe bony lesion, is reported. A 52-year-old male was admitted due to pain in both hips and for evaluation of hypercalcemia. The plasma level of the intact parathyroid hormone(iPTH) was elevated to 1424pg/mL. Ultrasonography and the computed tomography revealed a parathyroid cyst on the left thyroid lower pole. Parathyroid scintigraphy detected a parathyroid adenoma. A radiograph showed a subperiosteal bone resorption on the phalanges, and a brown tumor(osteitis fibrosa cystica) on the femur shaft was noted. A surgical excision of the parathyroid adenoma was performed. The PTH level in the cystic fluid was increased. A histological examination confirmed a cystic parathyroid adenoma. The PTH level was normalized after the operation.

The Significance of Plasma ADH in Differential Diagnosis of Central Diabetes Insipidus.: Ho Jong Lee, In Myung Yang, Sun Kee Min, Jung Hyun Noh, Cheol Young Park, Seung Joon Oh, Deog Yoon Kim, Jung Taek Woo, Sung Woon Kim, Jin Woo Kim, Young Seol Kim, Young Kil Choi; J Korean Endocr Soc. 2001;16(4-5):438-446. Published online October 1, 2001

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Abstract PDF: BACKGROUND
Although the water restriction test(WRT) has been used as a standard test for the differential diagnosis of diabetes insipidus(DI), the measurement of plasma ADH concentration is also known to be useful method for differential diagnosis. Recent studies have shown that some patients with idiopathic central DI(CDI) were found to have a lesion on follow-up imaging studies. There have been no report in Korea on plasma ADH measurement for the differential diagnosis of DI, nor on follow-up imaging study of the idiopathic CDI. METHODS: We retrospectively reviewed the clinical and laboratory findings of 26 patients(12 men, 14 women, age 9-65 years) with CDI, including pituitary MRI or CT scan, who had been diagnosed with WRT and had undergone plasma ADH concentration measurement. RESULTS: 1) Clinical features of the patients with complete CDI did not differ from those of patients with partial CDI. 2) Maximal urine osmolality of complete CDI and partial CDI were 168+/-69mOsm/kg and 431+/-141mOsm/kg, respectively, and the percentage increase in the urinary osmolality after ADH injection was 209+/-149% and 29+/-17%, respectively. 3) Among the 26 patients, 10 patients had their plasma ADH measured. Nine patients in this group were diagnosed as CDI by WRT and plasma ADH concentration of the 9 was compatible for CDI. The plasma ADH level was also inappropriately low in one patient who had been diagnosed with primary polydipsia by WRT, the patient was diagnosed as partial CDI. 4) The findings of follow-up MRI revealed isolated thickening of the pituitary stalk in two cases of idiopathic CDI diagnosed initially with MRI. CONCLUSION: This study suggests that the measurement of plasma ADH can ensure a better differential diagnosis between partial CDI and primary polydipsia, and that the patients with idiopathic CDI should be examined regularly with MRI brain scan, including the pituitary gland.

The Combined Pituitary Stimulation Test in Patients Suffered from Massive Postpartum Hemorrhage.: Sang Hwa Kim, In Myung Yang, Cheol Young Park, Seung Joon Oh, Deog Yoon Kim, Jeong Taek Woo, Sung Woon Kim, Jin Woo Kim, Young Seol Kim, Sun Woo Kim, Young Kil Choi; J Korean Endocr Soc. 2001;16(1):39-53. Published online February 1, 2001

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Abstract PDF: BACKGROUND
ackground: Sheehan's syndrome secondary to severe postpartum hemorrhage is one of the major causes of pituitary insufficiency in Korea. Most of these patients do not manifest symptoms or signs of gross endocrinopathies. Earlier detection of pituitary insufficiency is of clinical importance. The combined pituitary stimulation test that uses the four hypothalamic releasing hormones is a rapid, safe, and effective way to evaluate anterior pituitary function. However, the criteria for a normal response has not been established in Korea. METHODS: Combined anterior pituitary stimulation tests were performed on fourteen healthy women who had no history of endocrine disease. Combined tests of anterior pituitary reserve were done no forty-five patients who suffered from massive postpartum hemorrhage which required transfusing, along with subsequent shock or changing consciousness and in thirty-nine patients who experienced mild postpartum hemorrhage. RESULTS: 1) In the severe hemorrhage group, thirty-three of forty-five women (73.3%) showed blunted responses in more than one of the anterior pituitary hormones in the combined pituitary stimulation tests. However, in the mild hemorrhage group, only eighteen of thirty-nine women (46.2%) demonstrated blunted responses of more than one of the anterior pituitary hormones. 2) In the severe hemorrhage group, the TSH response was blunted in twenty-five patients (55.6%), prolactin in eleven patients (24.4%), ACTH in ten patients (22.2%), LH in ten patients (22.2%), GH in nine patients (20%), and FSH in five patients (11.1%). 3) The results of combined pituitary stimulation tests in the normal control group were different from the results of other studies. CONCLUSION: It is recommended that the women who experienced a severe postpartum hemorrhage should be evaluated by using the combined pituitary stimulation test. Moreover, criteria for a normal response to the combined pituitary stimulation test should be established in Korea.

Effect of Acute Hyperglycemia - and Isoproterenol - induced Hypothalamic Somatostatin Release on the Thyroid Hormone Releasing Hormone - induced Thyroid Stimulating Hormone Secretion.: Cheol Young Park, In Myung Yang, Seung Joon Oh, Deog Yoon Kim, Jeong Taek Woo, Sung Woon Kim, Jin Woo Kim, Young Seol Kim, Young Kil Choi; J Korean Endocr Soc. 2000;15(4-5):486-492. Published online January 1, 2001

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Abstract PDF: BACKGROUND
Acute hyperglycemia stimulates somatostatin (SRIH) release from the hypothalamus, and which in turn suppress growth hormone (GH) secretion and thyroid stimulating hormone (TSH) from the anterior pituitary gland. Beta-adrenergic pathway is known to stimulate the hypothalamus SRIH release. Recently, We demonstrated that isoproterenol, a beta-adrenergic agonist, had an additional suppressive effect on the suppression by glucose of GHRH-stimulated GH response. Therefore, the present study aimed to determine whether isoproterenol has an additional suppressive effect on the suppression by glucose of TRH-stimulated TSH response. METHODS: Seven healthy young men, aged 24 to 27 years, were studied. Four different TRH stimulation tests were carried out. (Test 1) TRH (Hoechst AG, Germany), 200 microgram bolus, was given intravenously at 0 minute. (Test 2) Glucose, 100 g, was given orally 30 min before TRH administration. (Test 3) Isoproterenol(Isuprel, Sanofi Winthrop, USA), 0.012 pg/kg, was infused continuously for 120 min after TRH administration. (Test 4) After pretreatment with glucose as Test 2, isoproterenol and TRH were administered as Test 3. RESULTS: Oral glucose ingestion significantly suppressed the TRH-stimulated TSH secretion. Isoproterenol infusion significantly suppressed the TRH-stimulated TSH secretion. Glucose-induced suppression of the TSH response was significantly greater than that by isoproterenol. 1soproterenol infusion after glucose pretreatment did not show any additional suppressive effect on the glucose-induced suppression of TSH response to TRH. CONCLUSION: The results suggest that isoproterenol infusion in addition to glucose pretreatment before the TRH stimulation test is not necessary for the development of stronger stimulation test for the hypothalamic somatostatin secretion.

The Effect of Slow Release Lanreotide in Korean Acromegalic Ratients.: Sang Hwa Kim, In Myung Yang, Kwang Sik Seo, Eul Soon Im, Seung Joon Oh, Deog Yoon Kim, Jeong Taek Woo, Sung Woon Kim, Jin Woo Kim, Young Seol Kim, Sun Woo Kim, Young Kil Choi; J Korean Endocr Soc. 1999;14(3):458-471. Published online January 1, 2001

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Abstract PDF: BACKGROUND
Previous studies have shown that somatostatin analogues such as octreotide are effective in suppressing GH and IGF-I levels in acromegaly. The recent availability of slow release lanreotide could avoid the inconveniences associated with either repeated subcutaneous injections or continuous infusions. We investigated the effects of the SR-lanreotide on clinical, biochemical and safety responses in five patients with acromegaly. And we investigated whether the response of the GH level to acute adrninistration of octreotide predicts the response after 12 weeks of treatment with the SR-lanreotide and whether the identification of gsp oncogene could be used as a therapeutic and prognostic clue in treatment with the SR-lanreotide. METHODS: We studied the effects of SR-lanreotide 30 mg administered intramuscularly biweekly for 12 weeks in five Korean acromegalic patients. Subjective improvements in the clinical symptoms of acromegaly and adverse reactions were recorded. During SR-lanreotide treatment, serum GH, IGF-I and IGFBP-3 concentrations were evaluated just before the next injection of the SR-lanreotide. Before the start of SR-lanreotide therapy the sensitivity of GH secretion to the octreotide was tested by measuring the effect of the acute response to 0.1 mg intravenously on plasma GH levels followed until 6 hours after administration of octreotide. Direct polymerase chain reaction sequencing of the gsp oncogene were performed. We compared the responses to SR-lanreotide in patients harboring gsp-positive and gsp-negative somatotroph adenomas. RESULTS: The treatment with SR-lanreotide for 12 weeks could suppress the GH level by more than 50% in four of five patients and normalize the IGF-I in two patients. No correlation was found between the GH level and IGF-I level at the end of the study. The IGFBP-3 level correlated with the IGF-I level in three of five patients. Although the initial GH response to octreotide tended to correlate with the IGF-I response after SR-lanreotide treatment, the results were statistically insignificant. The patients with gsp-positive tumor tended to show a better response to SR-lanreotide. During treatment, there was a reduction in the percentage of patients complaining of joint pain, fatigue, digital paresthesia, and hyperhydrosis. Changes in soft tissue swelling were documented by decreases in finger circumference. The common adverse events were abdominal discomfort, loose stool, and diarrhea. These events were decreased progressively. No patients discontinued the treatment of SR-lanreotide due to adverse events. CONCLUSION: This study showed that SR-lanreotide is effective in controlling acromegalic symptoms as well as GH and IGF-I hypersecretion. This treatment was well tolerated and more convenient for the patients. Further studies are required for clinical outcome of long-term SR-lanreotide treatment and cost-effective analysis.

Human IGF-I gene expression in normal and thyroid tumor tissues.: Sung Woon Kim, Hyun Ha Jang, Sang Mee Park, Deog Yoon Kim, Jeong Taek Woo, In Myung Yang, Jin Woo Kim, Young Seol Kim, Kwang Won Kim, Suck Hwan Koh, Sung Wha Hong, Young Kil Choi; J Korean Endocr Soc. 1993;8(4):414-421. Published online January 1, 2001

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Abstract PDF: No abstract available.

Thrombolytic effect of esterase on the cerebral thrombosis.: Deog Yoon Kim, Jeong Tack Woo, Jin Woo Kim, Young Seol Kim, Kwang Won Kim, Young Kil Choi; J Korean Endocr Soc. 1992;7(4):379-383. Published online January 1, 2001

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Abstract PDF: No abstract available.

Effects of human growth hormone treatment in healthy older female.: Jeong Tack Woo, Deog Yoon Kim, Sung Woon Kim, In Myung Yang, Jin Woo Kim, Young Seol Kim, Kwang Won Kim, Young Kil Choi, Jong Eun Park; J Korean Endocr Soc. 1992;7(4):352-357. Published online January 1, 2001

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Abstract PDF: No abstract available.

Review of clinical characteristics of primary hyperparathyroidism.: Hyung Keun Chung, Deog Yoon Kim, Jeong Taek Woo, Sang Woon Kim, In Myung Yang, Jin Woo Kim, Young Seol Kim, Kwang Won Kim, Young Kil Choi; J Korean Endocr Soc. 1992;7(3):234-242. Published online January 1, 2001

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Abstract PDF: No abstract available.

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